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ORCID: Affiliation: 3 Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE 68198, USA These authors contributed equally to this work

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The first step involves consultation with the prescribing healthcare provider to assess whether dose escalation is appropriate

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Several stressors increase aging-like process and activate microglia toward proinflammatory phenotype causing destruction of neurons (Brown and Vilalta, 2016)

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The main difference was that Exenatide 2.0mg [2.07% (95% CI: 2.93%, 1.22%)] was more effective in lowering fasting blood glucose, followed by Semaglutide 2.0mg and Semaglutide 1.0mg [2.51% (95%) CI: 3.00%, 2.02%)]

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However, the mechanisms are incompletely understood

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